This talk was presented by Prof Peter Hunter, University of Auckland and Prof Liesbet Geris, University of Liège and KU Leuven as part of the BIOREME Webinar Series. Following their talks Prof Salman Siddiqui chaired a discussion on opportunities and challenges for democratising mathematical modelling for the respiratory community. See below for the recording and talk information.
Professor Peter Hunter
Peter Hunter is a Distinguished Professor in bioengineering and the founding director of the Auckland Bioengineering Institute, co-director of Computational Physiology at Oxford University and holds honorary and visiting professorships at a number of Universities globally. He has held a number of roles in research institutes and scientific councils worldwide including, elected Fellow of The Royal Society (London and NZ),he World Council for Biomechanics, the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Medical & Biological Engineering (IAMBE). His major research interests include, using computational modelling to better understand human physiology in terms of structure and function of tissues, cells and proteins. He established the Physiome Project of the International Union of Physiological Sciences which provides a comprehensive framework for modelling the human body using computational methods, using accessible methods and databases.
Title: Standards and tools for modelling multiscale physiological systems
Abstract: The Physiome Committee of the International Union of Physiological Sciences (IUPS) has developed model encoding standards and associated open access software and model repositories for modelling physiological processes at all spatial scales. This talk will discuss the current state of this work and also a new journal (https://journal.physiomeproject.org/) that supports the publishing of FAIR models and data. I will also briefly discuss a new approach to multiscale physiological modelling which implements the laws of physics in a simple and consistent way across scales from proteins to whole-body systems physiology models.
Professor Liesbet Geris
Liesbet Geris is a Professor in Biomechanics and Computational Tissue Engineering at The University of Liège and KU Leuven in Belgium, where she is the scientific lead for the Prometheus platform for Skeletal Tissue Engineering. Her research focusses on the multi-scale and multi-physics modeling of biological processes. Liesbet is the current executive director of the Virtual Physiological Human Institute and the lead of the European Commission funded consortium, EDITH.
Title: Building the Virtual Human Twin: an ecosystem approach
Abstract: The EDITH consortium are working towards developing a sustainable ecosystem towards the use of Virtual Human Twin (VHT) models in personalised medicine. Professor Liesbet will introduce the project, particularly focussing on end users and the clinical community.
First draft of the roadmap towards Virtual Human Twin (VHT) & public infrastructure (EDITH project): https://zenodo.org/records/8200955
Clinical survey on in silico medicine (only for clinicians): https://www.surveymonkey.com/r/H7Q3KG5 (the first survey of this kind led to the following publication: https://pubmed.ncbi.nlm.nih.gov/37138727/)
VHT manifesto: way for all organisations to signal interest & support for VHT: www.virtualhumantwins.eu
Call for use cases: www.edith-csa.eu/call-for-use-cases/